Biological and mass spectrometry imaging
Visualise mechanisms, biodistribution, response or tissue-level effects.
Offer overview
What this offer helps you achieve
Visualise mechanisms, biodistribution, response or tissue-level effects.
Scientific and technical scope
I2C provides preclinical and human in vivo functional imaging, cellular/tissue/organ biological imaging and high-resolution mass spectrometry imaging. Capabilities include tumour growth monitoring, toxicity and metabolic imaging, tumour models, fluorescence/bioluminescence, MALDI-FTICR tissue distribution studies and molecular fate tracking.
Capabilities mobilised
Imaging
Application fields
Oncology
Use case: High-resolution mass spectrometry imaging
The MALDI-FTICR imaging approach developed by CARMeN at Carnot i2C can locate and quantify anticancer molecules such as carboplatin and temozolomide, and contrast agents such as Dotarem, in biological tissues, including mouse and pig brain sections.
Another application maps the distribution of oxaliplatin and its metabolites in ovary sections.
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